2nd funding period granted for CRC Transregio 274

The Collaborative Research Centre Transregio 274: “Checkpoints of Central Nervous System Recovery” will be funded by the DFG for a further four years.

In addition to the UMG, the Technical University of Munich and the Ludwig Maximilian University of Munich are also involved in the CRC. Spokesperson for the CRC in the upcoming funding period (2024-2027) is Prof. Alexander Flügel.

The aim of the CRC is to better understand the regulation of repair processes in the central nervous system (CNS). Various damage scenarios caused by inflammation, trauma or circulatory disorders are being investigated in order to identify control points that regulate the recovery of damaged nerve tissue. Injuries in the mammalian CNS often lead to persistent damage and loss of function and sometimes even to progressive neurological deficits. However, despite the low tolerance of the CNS to injury, the response to acute CNS injury can be variable, ranging from irreversible damage to almost complete recovery. The reasons for these different outcomes are unknown.

In the first funding period, the focus was on analyzing different damage models and the cellular reactions, changes in the cells and molecular signals that determine the recovery of CNS tissue. Based on these findings, approaches will be pursued in the second funding period that will make it possible to determine generally applicable principles of recovery processes in animal disease models and in human diseases. These findings should form the basis for developing new therapeutic strategies that specifically promote the inner regeneration potential of nerve cells and at the same time limit scarring of the tissue. Further information about the CRC can be found at www.sfb274.de/en.