Kaji S, Berghoff SA, Spieth L, Schlaphoff L, Sasmita AO, Vitale S, Büschgens L, Kedia S, Zirngibl M, Nazarenko T, Damkou A, Hosang L, Depp C, Kamp F, Scholz S, Ewers D, Giera M, Ischebeck T, Wurst W, Wefers B, Schifferer M, Willem M, Nave K-A, Haass C, Arzberger T, Jäkel S, Wirths O, Saher G, Simons M.
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.
Immunity  (2024), S1074-7613(24)00458-8. doi: 10.1016/j.immuni.2024.09.014. PMID 39419029.  [Pubmed]

Münchhalfen M, Görg R, Haberl M, Löber J, Willenbrink J, Schwarzt L, Höltermann C, Ickes C, Hammermann L, Kus J, Chapuy B, Ballabio A, Reichardt S, Flügel A, Engels N, Wienands J.
TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions.
Nat Commun  (2024), 15: 6971. doi: 10.1038/s41422-024-01004-4. PMID 39138218.  [Pubmed]

Hosang L, Flügel A, Odoardi F.
Body-brain axis: orchestrating immune responses.
Cell Res  (2024), 34: 757-758. doi: 10.1038/s41422-024-01004-4. PMID 39014217.  [Pubmed]

Kaurani L, Islam MR, Heilbronner U, Krüger DM, Zhou J, Methi A, Strauss J, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Pena T, Erlebach L, Bühler A, Budde M, Senner F, Kohshour MO, Schulte EC, Schmauß M, Reininghaus EZ, Juckel G, Kronenberg-Versteeg D, Delalle I, Odoardi F, Flügel A, Schulze TG, Falkai P, Sananbenesi F & Fischer A.
Regulation of zbp1 by mir-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice.
EMBO J  (2024), 43: 1420-1444. doi: 10.1038/s44318-024-00067-8. PMID 38528182.  [Pubmed]

Bagnoud M, Remlinger J, Massy M, Lodygin D, Salmen A, Chan A, Lühder F, Hoepner R.
In vivo and in vitro evidence for an interplay between the glucocorticoid receptor and the vitamin D receptor signaling.
Cells  (2023), 2612: 2291. doi: 10.3390/cells12182291. PMID 37759513.  [Pubmed]

Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich R, Nave K-A, Stassart RM.
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.
Nat Neurosci  (2023), 26: 1218-1228. doi: 10.1038/s41593-023-01366-9. PMID 37386131.  [Pubmed]

Weiß M, Hernandez LC, Gil Montoya DC, Löhndorf A, Krüger A, Kopdag M, Uebler L, Landwehr M, Nawrock M, Huber S, Woelk LM, Werner R, Failla AV, Flügel A, Dupont G, Guse AH, Diercks BP.
Adhesion to laminin-1 and collagen IV induces the formation of Ca²⁺ microdomains that sensitize mouse T cells for activation.
Sci Signal  (2023), 16: eabn9405. doi: 10.1126/scisignal.abn9405. PMID 37339181.  [Pubmed]

Wannemacher R*, Reiß A*, Rohn K, Lühder F, Flügel A, Baumgärtner W, Hülskötter K.
Ovalbumin-specific CD4+ and CD8+ T cells contribute to different susceptibility for Theiler’s murine encephalomyelitis virus persistence.
Front Immunol  (2023), 14: 1194842. doi: 10.3389/fimmu.2023.1194842. *equal contribution. PMID 37292191.  [Pubmed]

Hosang L, Löhndorf A, Dohle W, Rosche A, Marry S, Diercks B-P, Müller-Kirschbaum LC, Flügel LT, Potter BVL, Odoardi F, Guse AH*, Flügel A*.
2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca²⁺ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis.
Biochim Biophys Acta Mol Cell Res  (2023), 1870: 119485. doi: 10.1016/j.bbamcr.2023.119485. *equal contribution. PMID 37150482.  [Pubmed]

Ulaganathan VK, Vasileva MH.
A strategy for uncovering germline variants altering anti-tumor CD8 T cell response.
J Genet Genomics  (2023), 50: 353-361. doi: 10.1016/j.jgg.2023.01.001. PMID 36690075.  [Pubmed]

Hülskötter K, Lühder F, Leitzen E, Flügel A, Baumgärtner W.
CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis.
Front Immunol  (2023), 14: 1105432. doi: 10.3389/fimmu.2023.1105432. PMID 37090733.  [Pubmed]

Meyer-Heemsoth L, Mitschke K, Bier J, Schütz K, Villunger A, Legler TJ, Weber MS, Lühder F*, Reichardt HM*.
T cell energy metabolism is a target of glucocorticoids in mice, healthy humans, and MS patients.
Cells  (2023), 12: 450. doi: org/10.3390/cells12030450. *equal contribution PMID 36766792.  [Pubmed]

Doudin A, Riebeling T, Staab J, Menon PR, Lühder F, Wirths O, Vinkemeier U, Ivetic A & Meyer T.
Lack of stat1 co-operative DNA binding protects against adverse cardiac remodelling in acute myocardial infarction.
Front Cardiovasc Med  (2023), 10: 975012. doi: 10.3389/fcvm.2023.975012. PMID 36923955. *equal contribution  [Pubmed]

Daguano Gastaldi V, Wilke Justus B, Weidinger CA, Walter C, Barnkothe N, Teegen B, Luessi F, Stöcker W, Lühder F, Begemann M, Zipp F, Nave K-A, Ehrenreich H.
Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects.
Brain Behav Immun  (2023), 1088: 135-147. doi: 10.1016/j.bbi.2022.10.016. PMID 36323361.  [Pubmed]

Düking T, Spieth L, Berghoff SA, Piepkorn L, Schmidke AM, Mitkovski M, Kannaiyan N, Hosang L, Scholz P, Shaib AH, Schneider LV, Hesse D, Ruhwedel T, Sun T, Linhoff L, Trevisiol A, Köhler S, Pastor AM, Misgeld T, Sereda M, Hassouna I, Rossner M, Odoardi F, Ischebeck T, de Hoz L, Hirrlinger J, Jahn O, Saher G.
Ketogenic diet uncovers differential metabolic plasticity of brain cells.
Sci Adv  (2022), 8: eabo7639. doi: 10.1126/sciadv.abo7639. PMID 36112685.  [Pubmed]

Merlini A, Haberl M, Strauß J, Hildebrand L, Genc N, Franz J, Chilov D, Alitalo K, Flügel-Koch C, Stadelmann C, Flügel A*, Odoardi F*
Distinct roles of the meningeal layers in CNS autoimmunity.
Nat Neurosci  (2022), 25: 887-899. doi: 10.1038/s41593-022-01108-3. *equal contribution PMID 35773544.  [Pubmed]

Hosang L, Cugota Canals R, van der Flier FJ, Hollensteiner J, Daniel R, Flügel A* and Odoardi F*
The lung microbiome regulates brain autoimmunity.
Nature  (2022), 603: 138-144. doi: 10.1038/s41586-022-04427-4. *equal contribution PMID 35197636.  [Pubmed] [PDF]

Charabati M, Grasmuck C, Ghannam S, Bourbonnière L, Fournier AP, Lécuyer MA, Tastet O, Kebir H, Rébillard RM, Hoornaert C, Gowing E, Larouche S, Fortin O, Pittet C, Filali-Mouhim A, Lahav B, Moumdjian R, Bouthillier A, Girard M, Duquette P, Cayrol R, Peelen E, Quintana FJ, Antel JP, Flügel A, Larochelle C, Arbour N, Zandee S, Prat A.
DICAM promotes TH17 lymphocyte trafficking across the blood-brain barrier during autoimmune neuroinflammation.
Sci Transl Med (2022), 14: eabj0473. doi: 10.1126/scitranslmed.abj0473. PMID 34985970.  [Pubmed]

Arinrad S, Wilke JBH, Seelbach A, Doeren J, Hindermann M, Butt UJ, Steixner-Kumar, AA, Spieth L, Ronnenberg A, Pan H, Berghoff SA, Hollmann M, Lühder F, Nave K-A, Bechter K, Ehrenreich H.
NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: a mild encephalitis model with neuropsychiatric relevance.
Mol Psychiatry  (2022), 27: 4974-4983. doi: 10.1038/s41380-021-01392-8. PMID 34866134.  [Pubmed]

Gu F, Krüger A, Roggenkamp HG, Alpers R, Lodygin D, Jaquet V, Möckl F, Hernandez C LC, Winterberg K, Bauche A, Rosche A, Grasberger H, Kao JY, Schetelig D, Werner R, Schröder K, Carty M, Bowie AG, Huber S, Meier C, Mittrücker HW, Heeren J, Krause KH, Flügel A, Diercks BP, Guse AH.
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca²⁺ signaling during T cell activation.
Sci Signal  (2021), 14: eabe3800. doi: 10.1126/scisignal.abe3800. PMID 34784249.  [Pubmed]

Berghoff SA, Spieth L, Sun T, Hosang L, Depp C, Sasmita AO, Vasileva MH, Scholz P, Zhao Y, Krueger-Burg D, Wichert S, Brown ER, Michail K, Nave K-A, Bonn S, Odoardi F, Rossner M, Ischebeck T, Edgar JM, Saher G.
Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice.
Cell Rep (2021), 37: 109889. doi: org/10.1016/j.celrep.2021.109889. PMID 34706227.  [Pubmed]

Hülskötter K, Lühder F, Flügel A, Herder V, Baumgärtner W.
Tamoxifen application is associated with transiently increased loss of hippocampal neurons following virus infection.
Int J Mol Sci (2021), 22: 8486. doi: 10.3390/ijms22168486. PMID 34445189.  [Pubmed]

Wilke JBH, Hindermann M, Moussavi A, Butt UJ, Dadarwal R, Berghoff SA, Sarcheshmeh AK, Ronnenberg A, Zihsler S, Arinrad S, Hardeland R, Seidel J, Lühder F, Nave K-A, Boretius S, Ehrenreich H.
Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis.
Acta Neuropathol Commun (2021), 9: 121. doi: 10.1186/s40478-021-01214-6. PMID 34215338.  [Pubmed]

Hülskötter K, Jin W, Allnoch L, Hansmann F, Schmidtke D, Rohn K, Flügel A, Lühder F, Baumgärtner W, Herder V.
Double-edged effects of tamoxifen-in-oil-gavage on an infectious murine model for multiple sclerosis.
Brain Pathol (2021), 31: e12994. doi: 10.1111/bpa.12994. PMID 34137105.  [Pubmed]

Bier J*, Steiger SM*, Reichardt HM*, Lühder F*.
Protection of antigen-primed effector T cells from glucocorticoid-induced apoptosis in cell culture and in a mouse model of multiple sclerosis.
Front Immunol (2021), 12: 671258. doi: 10.3389/fimmu.2021.671258. PMID 34177911. *equal contribution [Pubmed]

Roggenkamp HG, Khansahib I, Hernandez LC, Zhang Y, Lodygin D, Krüger A, Gu F, Möckl F, Löhndorf A, Wolters V, Woike D, Rosche A, Bauche A, Schetelig D, Werner R, Schlüter H, Failla AV, Meier C, Fliegert R, Walseth TF, Flügel A, Diercks BP, Guse AH.
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation.
Sci Signal  (2021), 14: eabd5647. doi: 10.1126/scisignal.abd5647. PMID 33758062. [Pubmed]

Reichardt SD, Amouret A, Muzzi C, Vettorazzi S, Tuckermann JP, Lühder F, Reichardt HM.
The Role of Glucocorticoids in Inflammatory Diseases.
Cells (2021), 10: 2921. doi: org/10.3390/cells10112921. PMID 34831143. [Pubmed]

Reichardt SD, Lühder F, Wiegers GJ, Reichardt HM.
A flow cytometric approach to study glucocorticoid receptor expression in immune cell subpopulations of genetically engineered mice.
Immunol Lett (2021), 233: 68-79. doi: 10.1016/j.imlet.2021.03.010. PMID 33753134. [Pubmed]

Löhndorf A*, Hosang L*, Dohle W, Odoardi F, Waschkowski S-A, Rosche A, Bauche A, Winzer R, Tolosa E, Windhorst S, Marry S, Flügel A, Potter BVL, Diercks B-P, Guse AH.
2-Methoxyestradiol and its derivatives inhibit store-operated Ca 2+ entry in T cells: identification of a new and potent inhibitor.
Biochim Biophys Acta Mol Cell Res (2021), 1868: 118988. doi: 10.1016/j.bbamcr.2021.118988. Online ahead of print. PMID 33581218. *equal contribution [Pubmed]

Winkler A, Wrzos C, Haberl M, Weil M-T, Gao M, Möbius W, Odoardi F, Thal DR, Chang M, Opdenakker G, Bennett JL, Nessler S, Stadelmann C.
Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration.
J Clin Invest (2021), 131: 141694. doi: 10.1038/s41593-020-00757-6. PMID 33645550. [Pubmed]

Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G.
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
Nat Neurosci (2021), 24: 47-60. doi: 10.1038/s41593-020-00757-6. PMID 33349711. [Pubmed]

Pan H, Steixner-Kumar AA, Seelbach A, Deutsch N, Ronnenberg A, Tapken D, von Ahsen N, Mitjans M, Worthmann H, Trippe R, Klein-Schmidt C, Schopf N, Rentzsch K, Begemann M, Wienands J, Stöcker W, Wiessenborn K, Hollmann M, Nave KA, Lühder F, Ehrenreich H.
Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury.
Mol Psychiatry  (2021), 26: 2471-2482. doi: 10.1038/s41380-020-0672-1. PMID 32089545. [Pubmed]

Riebeling T, Jamal K, Wilson R, Kolbrink B, von Samson-Himmelsjerna, FA, Moerke C, Ramos Garcia L, Dahlke E, Michels F, Lühder F, Schunk D, Doldi P, Tyczynski B, Kribben A, Flüh C, Theilig F, Kunzendorf U, Meier P, Krautwald S
Primidone blocks RIPK1-driven cell death and inflammation.
Cell Death Differ (2021), 28: 1610-1626. doi: 10.1038/s41418-020-00690-y. PMID 33273695. [Pubmed]

Ulaganathan VK
TraPS-VarI: Identifying genetic variants altering phosphotyrosine based signalling motifs.
Sci Rep (2020), 10: 8453. doi: 10.1038/s41598-020-65146-2. PMID 32439998. [Pubmed]

Li Z, Korhonen EA, Merlini A, Strauß J, Wihuri E, Nurmi H, Antila S, Paech J, Deutsch U, Engelhardt B, Chintharlapalli S, Koh GY, Flügel A, Alitalo K.
Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS.
J Clin Invest (2020), 130: 1977-1990. doi: 10.1172/JCI130308. PMID 32149735. [Pubmed]

Hauptmann J, Johann L, Marini F, Kitic M, Colombo E, Mufazalov IA, Krueger M, Karram K, Moos S, Wanke F, Kurschus F, Klein M, Cardoso S, Strauß J, Bolisetty S, Lühder F, Schwaninger M, Binder H, Bechman I, Bopp T, Agarwal A, Soares MP, Regen T, Waisman A.
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier.
Acta Neuropathol (2020), 140: 549-567. doi: 10.1007/s00401-020-02187-x. PMID 32651669. [Pubmed]

Thiele Née Schrewe L, Guse K, Tietz S, Remlinger J, Demir S, Pedreiturria X, Hoepner R, Salmen A, Pistor M, Turner T, Engelhardt B, Hermann D, Lühder F, Wiese S, Chan A.
Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis.
J Neuroinflammation (2020), 17: 9. doi: 10.1186/s12974-019-1677-z. PMID 31915017. [Pubmed]

Hoepner R, Bagnoud M, Pistor M, Salmen A, Briner M, Synn H, Schrewe L, Guse K, Ahmadi F, Demir S, Laverick L, Gresle M, Worley P, Reichardt HM, Butzkueven H, Gold R, Metz I, Lühder F, Chan A.
Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis.
Acta Neuropathol (2019), 138: 443-456. doi: 10.1007/s00401-019-02018-8. PMID 31030237. [Pubmed]

Mundt S, Greter M, Flügel A, Becher B.
The CNS immune landscape from the viewpoint of a T cell.
Trends Neurosci (2019), 42: 667-679. doi: 10.1016/j.tins.2019.07.008. PMID 31474310. [Pubmed]

Li H, Kaiser TK, Borschiwer M, Bohnenberger H, Reichardt SD, Lühder F, Walter L, Dressel R, Meijsing SH, Reichardt HM.
Glucocorticoid resistance of allogeneic T cells alters the gene expression profile in the inflamed small intestine of mice suffering from acute graft-versus-host disease.
J Steroid Biochem Mol Biol (2019), 195: 105485. doi: 10.1016/j.jsbmb.2019.105485. PMID 31561002. [Pubmed]

Fischer HJ, Finck TLK, Pellkofer HL, Reichardt HM, Lühder F.
Glucocorticoid therapy of multiple sclerosis patients induces anti-inflammmatory polarization and increased chemotaxis of monocytes.
Front Immunol (2019), 10: 1200. PMID 31191554. [Pubmed]

Lodygin D⁺, Hermann M⁺, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang H-F, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Frahm J, Stadelmann C, Kügler S, Fitzner D, Haberl M, Odoardi F* & Flügel A*⁺equal contribution, * co-senior authors
β-Synuclein reactive T cells induce autoimmune CNS grey matter degeneration.
Nature (2019), 566: 503-508. PMID 30787438. [Pubmed]

Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.
Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.
Hum Mol Genet (2019), 28: 31-50. PMID 30219847. [Pubmed]

Pan H, Oliveira B, Saher G, Dere E, Tapken D, Mitjans M, Seidel J, Wesolowski J, Wakhloo D, Klein-Schmidt C, Ronnenberg A, Schwabe K, Trippe R, Mätz-Rensing K, Berghoff S, Al-Krinawe Y, Martens H, Begemann M, Stöcker W, Kaup FJ, Mischke R, Boretius S, Nave KA, Krauss JK, Hollmann M, Lühder F, Ehrenreich H.
Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.
Mol Psychiatry (2019), 24: 1489-1501. doi: 10.1038/s41380-017-0011-3. [Pubmed]

Baake T, Jörß K, Suennemann J, Roßmann L, Bohnenberger H, Tuckermann JP, Reichardt HM, Fischer HJ, Reichardt SD.
The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay.
Oncotarget, 9 (2018): 15437-15450. PMID 29643984. [Pubmed.]

Uri A, Lühder F, Kerkau T, Beyersdorf N.
During acute graft versus host disease CD28 deletion in donor CD8⁺, but not CD4⁺, T cells maintain antileukemia responses in mice.
Eur J Immunol, 48 (2018): 2055-2067. [Pubmed.]
 
Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH.
ORAI1, STIM1/2, and RYR1 shape subsecond Ca²⁺ microdomains upon T cell activation.
Sci Signal, 11 (2018): pii: eaat0358. doi: 10.1126/scisignal.aat0358. [Pubmed.]

Mausberg AK, Szepanowski, F, Odoardi F, Flügel A, Kleinschnitz K, Stettner M, Kieseier BC.
Trapped in the epineurium: Early entry into the endoneurium is restricted to neuritogenic T cells in experimental autoimmune neuritis.
J Neuroinflamm, 15 (2018): 217, doi:10.1186/s12974-018-1259-5. [Pubmed]

Langenhorst D, Haack S, Göb S, Uri A, Lühder F, Vanhove B, Hünig T, Beyersdorf N.
CD28 Costimulation of T helper 1 cells enhances cytokine release in vivo.
Front Immunol, 9 (2018): 1060, doi:10.3389/fimmu.2018.01060. [Pubmed]

Meers GK, Bohnenberger H, Reichardt HM, Lühder F, Reichardt SD .
Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells.
PLoS One, 13 (2018): e0190846, doi: 10.1371/journal.pone.0190846. [Pubmed]

Montes-Cobos E, Schweingruber N, Li X, Fischer H, Reichardt HM, Lühder F.
Deletion of the mineralocorticoid receptor in myeloid cells attenuates central nervous system autoimmunity.
Front Immunol, 8 (2017): 1319, doi.org/10.3389/fimmu.2017.01319. [Pubmed]

Puchert M, Pelkner F, Stein G, Angelov DN, Boltze J, Wagner DC, Odoardi F, Flügel A, Streit WJ, Engele J.
Astrocytic expression of the CXCL12 receptor, CXCR7/ACKR3 is a hallmark of the diseased, but not developing CNS.
Mol Cell Neurosci, 85 (2017): 105-118. [Pubmed]

Lühder F & Reichardt HM.
Novel drug delivery systems tailored for improved administration of glucocorticoids.
Int J Mol Sci, 18 (2017): pii E1836. doi: 10.3390/ijms18091836. [Pubmed]

Uri A, Werner S, Lühder F, Hünig T, Kerkau T, Beyersorf N.
Protection of mice from acute graft-versus-host disease requires CD28 co-stimulation on donor CD4+ Foxp3+ regulatory T cells.
Front Immunol, 8 (2017). doi: 10.3389/fimmu.2017.00721 [Epub ahead of print] [Pubmed]

Lagumersindez-Denis N, Wrzos C, Mack M, Winkler A, van der Meer F, Reinert MC, Hollasch H, Flach A, Brühl H, Cullen E, Schlumbohm C, Fuchs E, Linington C, Barrantes-Freer A, Metz I, Wegner C, Liebetanz D, Prinz M, Brück W, Stadelmann C, Nessler S.
Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis.
Acta Neuropathol, 134 (2017): 15-34. [Pubmed]

Klaßen C, Karabinskaya A, Dejager L, Vettorazzi S, Van Moorleghem J, Lühder F, Meijsing SH, Tuckermann JP, Bohnenberger H, Libert C, Reichardt HM.
Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma.
J Immunol, 199 (2017): 48-61. [Pubmed]

Lodygin D, Flügel A.
Intravital real-time analysis of T-cell activation in health and disease.
Cell Calcium, 64 (2017): 118-129. [Pubmed]

Berghoff SA, Gerndt N, Winchenbach J, Stumpf SK, Hosang L, Odoardi F, Ruhwedel T, Böhler C, Barrette B, Stassart R, Liebetanz D, Dibaj P, Möbius W, Edgar JM, Saher G
Dietary cholesterol promotes repair of demyelinated lesions in the adult brain.
Nat Commun, 8 (2017): 14241. [Pubmed]

Engler JB, Kursawe N, Solano ME, Patas K, Wehrmann S, Heckmann N, Lühder F, Reichardt HM, Arck PC, Gold SM, Friese MA
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proc Natl Acad Sci USA, 114 (2017): E181-E190. [Pubmed]

Lühder F, Kebir H, Odoardi F, Litke T, Sonneck M, Alvarez JI, Winchenbach J, Eckert N, Hayardeny L, Sorani E, Lodygin D, Flügel A, Prat A.
Laquinimod enhances central nervous system barrier functions.
Neurobiol Dis, 102 (2017): 60-69. [Pubmed]

Montes-Cobos E, Ring S, Fischer HJ, Heck J, Strauß J, Schwaninger M, Reichardt SD, Feldmann C, Lühder F, Reichardt HM.
Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles.
J Control Release, 245 (2017): 157-169. [Pubmed]

Winter M, Lodygin D, Verdoodt B, Hermeking H.
Deletion of 14-3-3σ sensitizes mice to DMBA/TPA-induced papillomatosis.
Oncotarget 7 (2016): 46862-46870. [Pubmed]

Flach A, Litke T, Strauss J, Haberl M, Cordero Gómez C, Reindl M, Saiz A, Fehling HJ, Wienands J, Odoardi F, Lühder F, Flügel A.
Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease.
Proc Natl Acad Sci USA, 113: 3323-3328. [Pubmed]

Schläger C, Körner H, Krueger M, Vidoli S, Haberl M, Mielke D, Brylla E, Issekutz T, Cabañas C, Nelson PJ, Ziemssen T, Rohde V, Bechmann I, Lodygin D, Odoardi F, Flügel A.
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid.
Nature 530 (2016): 349-353. [Pubmed]

Engelhardt B, Carare RO, Bechmann I, Flügel A, Laman JD, Weller RO.
Vascular, glial, and lymphatic immune gateways of the central nervous system.
Acta Neuropathol 132 (2016): 317-338. [Pubmed]

Fröhlich M, Gogishvili T, Langenhorst D, Lühder F, Hünig T.
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
Eur J Immunol (2016): 1644-1655. [Pubmed]

Andresen L, Theodorou K, Grünewald S, Czech-Zechmeister B, Könnecke B, Lühder F, Trendelenburg G.
Evaluation of the therapeutic potential of anti-TLR4-antibody MTS510 in experimental stroke and significance of different routes of application.
PLOS One 11 (2016): doi: 10.1371/journal.pone.0148428. [Pubmed]

Fischer HJ, van den Brandt J, Lingner T, Odoardi F, Flügel A, Weishaupt A, Reichardt HM.
Modulation of CNS autoimmune responses by CD8(+) T cells coincides with their oligoclonal expansion.
J Neuroimmunol 290 (2016): 26-32. [Pubmed]

Schläger C, Litke T, Flügel A, Odoardi F.
In vivo visualization of (auto)immune processes in the central nervous system of rodents.
Methods Mol Biol 1304 (2016): 117-129. [Pubmed]

Heuer L, Beyerbach M, Lühder F, Beineke A, Strube C.
Neurotoxocarosis alters myelin protein gene transcription and expression.
Parasitol Res 114 (2015): 2175-2186. [Pubmed]

Krey L, Lühder F, Kusch K, Czech-Zechmeister B, Könnecke B, Outeiro TF, Trendelenburg G.
Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.
J Cereb Blood Flow Metab 35 (2015): 2080-2088. [Pubmed]

Linker RA, Lee H, Flach A, Litke T, van den Brandt J, Reichardt HM, Lingner T, Bommhardt U, Sendtner M, Gold R, Flügel A, Lühder F.
Thymocyte-derived BDNF influences T cell maturation at the DN3/DN4 transition stage.
Eur J Immunol 45 (2015): 1326-1338. [Pubmed]

Chan A & Lühder F.
Experimentelle Grundlagen neuroimmunologischer Erkrankungen.
In Fragen und Antworten zur Neuroimmunologie (Wiendl, H., Kieseier, B. C., and Meuth, S. G., eds) (2015): 7-26, Hogrefe Verlag, Bern.

Muth IE, Zschüntzsch J, Kleinschnitz K, Wrede A, Gerhardt E, Balcarek P, Schreiber-Katz O, Zierz S, Dalakas MC, Voll RE, Schmidt J.
HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis.
Exp Neurol 271 (2015): 189-197. [Pubmed]

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.
Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.
Glia 63 (2015): 1083-1099. [Pubmed]

Nebel M, Zhang B, Odoardi F, Flügel A, Potter BVL, Guse AH.
Calcium signalling triggered by NAADP in T cells determines cell shape and motility during immune synapse formation.
Messenger 4 (2015): 104-111.

Theiss-Suennemann J, Jörß K, Messmann JJ, Reichardt SD, Montes-Cobos E, Lühder F, Tuckermann JP, AWolff H, Dressel R, Gröne HJ, Strauß G, Reichardt HM.
Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8+ T cells.
J Pathology 235 (2015): 646-655. [Pubmed]

Wolf IM, Diercks BP, Gattkowski E, Czarniak F, Kempski J, Werner R, Schetelig D, Mittrücker HW, Schumacher V, von Osten M, Lodygin D, Flügel A, Fliegert R, Guse AH.
Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.
Sci Signal 8 (2015): ra102. doi: 10.1126/scisignal.aab0863 [Pubmed]

Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H.
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity.
Mol Psychiatry 19 (2014): 1143-1149. [Pubmed]

Reichardt SD, Weinhage T, Rotte A, Föller M, Oppermann M, Lühder F, Tuckermann JP, Lang F, van den Brandt J, Reichardt HM.
Glucocorticoids Induce Gastroparesis in Mice Through Depletion of l-Arginine.
Endocrinology 155 (2014): 3899-3908. [Pubmed]

Odoardi F, Neuhuber W, Flügel A.
Pain-induced skin autoimmunity.
Research Highlight in Cell Research 24 (2014): 1021-1022.[Pubmed]

Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D, Kaller M, Horst D, Ziegler PK, Schwitalla S, Slotta-Huspenina J, Bader FG, Greten FR, Hermeking H.
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
J Clin Invest 124 (2014): 1853-1867. [Pubmed]

Uhmann A, Heß I, Frommhold A, König S, Zabel S, Nitzki F, Dittmann K, Lühder F, Christiansen H, Reifenberger J, Schulz-Schaeffer W, Hahn H.
DMBA/TPA Treatment Is Necessary for BCC Formation from Patched Deficient Epidermal Cells in Ptchflox/floxCD4Cre+/- Mice.
J Invest Dermatol. (2014); 134(10):2620-9. [Pubmed]

Lühder F & Gold R.
Trial and error in clinical studies: lesson from ATAMS.
Comment in Lancet Neurol 13 (2014): 340-341. [Pubmed]

Schweingruber N+, Fischer HJ+, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tickermann J, Flügel A, Lühder F*, Reichardt HM*.
Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.
Acta Neuropathol 127 (2014): 713-729 +* equal contribution [Pubmed]

Carstens PO, Schmidt J.
Diagnosis, pathogenesis and treatment of myositis: recent advances.
Clin Exp Immunol 175 (2014): 349-358 [Pubmed]

Ndlovu H, Darby M, Froelich M, Horsnell W, Lühder F, Hünig T, Brombacher F.
Inducible deletion of CD28 prior to secondary Nippostrongylus brasiliensis invection impairs worm expulsion and recall of protective memory CD4+ T cell responses.
PLOS Pathogens 10 (2014): e1003906. [Pubmed]

Simma N, Bose T, Kahlfuß S, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U .
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Cell Commun signal 12 (2014): 75. [Pubmed]

Li W, Holsinger RM, Kruse CA, Flügel A, Graeber MB.
The potential for genetically altered microglia to influence glioma treatment.
CNS Neurol Disord Drug Targets 12 (2013): 750-762. [Pubmed]

Fischer HJ, Schweingruber N, Lühder F, Reichardt HM.
The potential role of T cell migration and chemotaxis as targets of glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis.
Mol Cell Endocrinol 380 (2013): 99-107. [Pubmed]

Lodygin D, Odoardi F, Schläger C, Körner H, Kitz A, Nosov M, van den Brandt J, Reichardt HM, Haberl M, Flügel A.
A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity.
Nat Med 19 (2013): 784-790. [Pubmed]

Fang H, Liu A, Sun J, Kitz A, Dirsch O, Dahmen U.
Granulocyte colony stimulating factor induces lipopolysaccharide (LPS) sensitization via upregulation of LPS binding protein in rat.
PLoS One 8 (2013): e56654. doi: 10.1371/journal.pone.0056654. Epub 2013 Feb 20. [Pubmed]

Gogishvili T, Lühder F, Goebbels S, Beer-Hammer S, Pfeffer K, Hünig T.
Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion.
Eur J Immunol 43 (2013): 188-193. [Pubmed] David Sansom & Lucy Walker commentary [Pubmed commentary]

Lühder F, Gold R, Flügel A, Linker RA.
Brain-Derived Neurotrophic Factor in Neuroimmunology: Lessons Learned from Multiple Sclerosis Patients and Experimental Autoimmune Encephalomyelitis Models.
Arch Immunol Ther Exp (Warsz). 2013 Apr;61(2):95-105 [Pubmed]

Graeber MB, Banati RB, Flügel A, Streit WJ, Tetzlaff W.
Courage, luck and patience: in celebration of the 80th birthday of Georg W. Kreutzberg.
Acta Neuropathol 124 (2012): 593-598. [Pubmed]

Gogishvili T, Lühder F, Kirstein F, Nieuwenhuizen NE, Goebbels S, Beer-Hammer S, Pfeffer K, Reuter S, Taube C, Brombacher F, Hünig T.
Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease.
J Allergy Clin Immunol 130 (2012): 1394-1403. [Pubmed]

Wüst S, van den Brandt J, Reichardt HM, Lühder F.
Preventive treatment with methylprednisolone paradoxically exacerbates experimental autoimmune encephalomyelitis.
J Endocrinol (2012): doi: 10.1155/2012/417017. [Pubmed]

Reichardt HM, Lühder F.
The ambivalent role of apoptosis in experimental autoimmune encephalomyelitis and multiple sclerosis.
Curr Pharm Des 18 (2012): 4453-4464. [Pubmed]

Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schläger C,Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WE, Lottaz C, Nosov M, Brinkmann V, Spang R, Lehrach H, Vingron M, Wekerle H, Flügel-Koch C, Flügel A.
T cells become licensed in the lung to enter the central nervous system.
Nature 488 (2012): 675-679. [Pubmed]. Richard M. Ransohoff commentary in Nature.

Treacy O, Ryan AE, Heinzl T, O’Flynn L, Cregg M, Wilk M, Odoardi F, Lohan P, O’Brien T, Nosov M, Ritter T.
Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation.
PLoS One. 2012;7(8):e42662. Epub 2012 Aug 6. [Pubmed]

Frank T, Klinker F, Falkenburger BH, Laage R, Lühder F, Göricke B, Schneider A, Neurath H, Desel H, Liebetanz D, Bähr M, Weishaupt JH.
Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson’s disease.
Brain 135 (2012): 1914-1925. [Pubmed]

Schmidt J, Barthel K, Zschüntzsch J, Muth I, Swindle E, Hombach A, Sehmisch S, Wrede A, Lühder F, Gold R, Dalakas M.
Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1beta-induced accumulation of beta-amyloid and cell death.
Brain 135 (2012): 1102-1114. [Pubmed]

Wekerle H, Flügel A, Fugger L, Schett G, Serreze D.
Autoimmunity’s next top models.
Nature Medicine 18 (2012): 66-70. [Pubmed]

Lee DH, Geyer E, Flach AC, Jung K, Gold R, Flügel A, Linker RA, Lühder F.
Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination.
Acta Neuropathol 123 (2012) 247-258 [Pubmed]

Schweingruber N, Reichardt SD, Lühder F, Reichardt HM.
Mechanisms of glucocorticoids in the control of neuroinflammation.
J Neuroendocrinol. 24 (2012): 174-182. [Pubmed]

Flügel A, Schläger C, Lühder F, Odoard Fi.
Autoimmune disease in the brain – how to spot the culprits and how to keep them in check.
Journal of Neurological Sciences 311 S1(2011): S3–S11. (Pubmed)

Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, Karow U, Herold MJ, Lühder F, Utermöhlen O, Reichardt HM.
Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death.
J Immunol (2011) doi: 10.4049/ J Immunol 187 (2011):4509-4516. [Pubmed]

Schweingruber N, Haine A, Tiede K, Karabinskaya A, van den Brandt J, Wüst S, Metselaar JM, Gold R, Tuckermann JP, Reichardt HM, Lühder F.
Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis.
J Immunol 187 (2011):4310-4318. [Pubmed]

Miljkovic D, Stanojevic Z, Momcilovic M, Odoardi F, Flügel A, Mostarica-Stojkovic M.
CXCL12 expression within the CNS contributes to the resistance against experimental autoimmune encephalomyelitis in Albino Oxford rats.
Immunobiology 216 (2011): 979-987. [Pubmed]

Keller CW, Fokken C, , Turville S, Lünemann A, Schmidt J, Münz C, Lünemann JD.
TNF-alpha induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells.
J Biol Chem 286 (2011): 3970-3980. [Pubmed]

Uhmann A, van den Brandt J, Dittmann K, Hess I, Dressel R, Binder C, Lühder F, Christiansen H, Fassnacht M, Bhandoola A, Wienands J, Reichardt HM, Hahn H.
T cell development critically depends on prethymic stromal patched expression.
J Immunol 186 (2011) 3383-91. [Pubmed]

Bartl J, Link P, Schlosser C, Gerlach M, Schmitt A, Walitza S, Riederer P, Grünblatt E.
Effects of methylphenidate: the cellular point of view.
Atten Def Hyp Disord 2 (2010): 225-232. [Pubmed]

Linker RA, Lee DH, Demir S, Wiese S, Kruse N, Siglienti I, Gerhardt E, Neumann H, Sendtner M, Lühder F, Gold R.
Functional role of brain-derived neurotrophic factor in neuroprotective autommunity: therapeutic implications in a model of multiple sclerosis.
Brain 133 (2010): 2248-2263. [Pubmed]

Shevtsova Z, Garrido M, Weishaupt J, Saftig P, Bähr M, Lühder F, Kügler S.
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
Am J Pathol 177 (2010): 271-9. [Pubmed]

Hünig T, Lühder F, Elflein K, Gogishvili T, Fröhlich M, Guler R, Cutler A, Brombacher F.
CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation.
Med Microbiol Immunol 199 (2010): 239-46. [Pubmed]

Volovitz I, Marmor Y, Mor F, Flügel A, Odoardi F, Eisenbach L, Cohen IR.
T cell vaccination induces the elimination of EAE effector T cells: analysis using GFP-transduced, encephalitogenic T cells.
J. Autoimmunity (2010) Sep; 35(2): 135-44. Epub 2010 Jun 26. [Pubmed]

Cordiglieri C, Odoardi F, Zhang B, Nebel M, Kawakami N, Klinkert WE, Lodygin D, Lühder F, Breunig E, Schild D, Ulaganathan VK, Dornmair K, Dammermann W, Potter BV, Guse AH, Flügel A.
NAADP-mediated Ca2+ signaling in effector T cells regulates autoimmunity of the nervous system.
Brain 133 (2010): 1930-43. [Pubmed]

Kawakami N, Flügel A.
Knocking at the brain’s door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures.
Seminars in Immunopathology (2010) Sep; 32(3): 275-87. [Pubmed]

Lühder F, Lee DH, Gold R, Stegbauer J, Linker RA.
Small but powerful: Short peptide hormones and their role in autoimmune inflammation.
Journal of Neuroimmunology 217 (2009), 1-7. [Pubmed]

Wüst S, Tischner D, John M, Tuckermann JP, Menzfeld C, Hanisch UK, van den Brandt J, Lühder F, Reichardt HM.
Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of Multiple Sclerosis.
PLoS ONE (2009) 4(12): e8202. [Pubmed]

Muth IE, Barthel K, Bähr M, Dalakas MC, Schmidt J.
Pro-inflammatory cell stress in sIBM muscle: overexpression of αB-crystallin is associated with amyloid precursor protein and accumulation of β-amyloid.
Journal of Neurology, Neurosurgery & Psychiatry 80 (2009): 1344-1349. [Pubmed]

Bartholomäus I, Kawakami N, Odoardi F, Schläger C, Miljkovic D, Ellwart JW, Klinkert WE, Issekutz TB, Flügel-Koch C, Wekerle H, Flügel A.
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.
Nature 462 (2009):94-8. [Pubmed]

Rooney GE, McMahon SS, Ritter T, Garcia Y, Moran C, Madigan NN, Flügel A, Dockery P, O’Brien T, Howard L, Windebank AJ, Barry FP.
Glial-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Survive Transplantation Into the Contused Spinal Cord Without Differentiating Into Neural Cells.
Tissue Engineering 15 (2009): 3049-59. [Pubmed]

Tischner D, van den Brandt J, Weishaupt A, Lühder F, Herold MJ, Reichardt HM.
Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNAs: insight into neuroinflammatory disease.
European Journal of Immunology. 39 (2009), 2361-70. [Pubmed]

Cotte S, von Ahsen N, Kruse N, Huber B, Winkelmann A, Zettl UK, Starck M, König N, Tellez N, Dörr J, Paul F, Zipp F, Lühder F, Koepsell H, Pannek H, Montalban X, Gold R, Chan A.
ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis.
Brain 132 (2009), 2517-30. [Pubmed]

Kichberger T, Moreau C, Wagner GK, Fliegert R, Siebrands CC, Nebel M, Schmid F, Harneit A, Odoardi F, Flügel A, Potter BV, Guse AH.
8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.
Biochemical Journal, 422 (2009):139-49. [Pubmed]

Dammermann W+, Zhang B+, Nebe Ml+, Cordiglieri C+, Odoardi F, Kirchberger T, Kawakami N, Dowden J, Schmid F, Dornmair K, Hohenegger M, Flügel AF*, Guse*AH, Potter BV.
Potter* NAADP mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist.
Proceedings of the National Academy of Sciences of the United States of America 106 (2009):10678-83. [Pubmed]

Dalakas MC, Rakocevic G, Schmidt J, Salajegheh M, McElroy B, Harris-Love MO, Shrader JA, Levy JAE, Dambrosia J, Kampen RL, Bruno DA, Kirk AD.
Effect of Alemtuzumab (Campath 1-H) in patients with Inclusion Body Myositis.
Brain 132 (2009): 1536-1544. [Pubmed]

Lühderand F, Reichardt H.
Traditional concepts and future avenues of glucocorticoid action in experimental autoimmune encephalomyelitis and multiple sclerosis therapy.
Critical Reviews in Immunology 29 (2009), 255-73. [Pubmed]

Schmidt J.
Pathogenesis of sporadic Inclusion Body Myositis: Significance of Inflammation and Implications for Therapeutic Strategies.
Aktuelle Neurologie 36 (2009): 121-125.

Linker RA, Gold R, Lühder F.
Function of neurotrophic factors beyond the nervous system: Inflammation and autoimmune demyelination.
Critical Reviews in Immunology 29 (2009), 43-68. [Pubmed]

Gogishvili T, Langenhorst D, Lühder F, Elias F, Elflein K, Dennehy KM, Gold R, Hünig T.
Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.
PLoS ONE. (2009); 4(2):e4643. [Pubmed]

Gold R, Lühder F.
Interleukin-17: Extended Features of a Key Player in Multiple Sclerosis.
American Journal of Pathology 172 (2008), 8-10. [Pubmed]

Rostasy KM, Schmidt J, Bahn E, Pfander T, Piepkorn M, Wilichowski E, Schulz-Schaeffer WJ.
Distinct inflammatory properties of late-activated macrophages in inflammatory myopathies.
Acta Myologica 27 (2008): 49-53. [Pubmed]

Schmidt J, Dalakas MC.
Inflammation interrelates to APP in sIBM: IL-1beta induces accumulation of beta-amyloid.
Brain 2008; (letter, available online only, doi:10.1093/brain/awn164). [Brain]

Schmidt J, Barthel K, Wrede A, Salajegheh M, Bähr M, Dalakas MC.
Interrelation of inflammation and APP in sIBM: IL-1beta induces accumulation of beta-amyloid in skeletal muscle.
Brain 131 (2008): 1228-1240. [Pubmed]

Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD.
In situ imaging of effector/memory T cells during DTH and suppression by Kv1.3 channel block.
Immunity 29 (2008): 602-14. [Pubmed]

Müller N, van den Brandt J, Odoardi F, Tischner D, Herath J, Flügel A, Reichardt HM.
CD28 superagonistic antibodies elicit two functionally distinct waves of T cell activation.
Journal of Clinical Investigation 118(2008):1405-1416. [Pubmed]

Linker R, Kruse N, Israel S, Wei T, Seubert S, Hombach A, Holtmann B, Lühder F, Ransohoff RM, Sendtner M, Gold R.
LIF-deficiency modulates the immune response and limits autoimmune demyelination: a new role for neurotrophic cytokines in neuroinflammation.
Journal of Immunology. 180 (2008), 2204-13. [Pubmed]

Rooney GE, Moran C, McMahon SS, Ritter T, Maenz M, Flügel A, Dockery P, O’ Brien T, Howard L, Windebank AJ, Barry FB.
Gene-Modified Mesenchymal Stem Cells Express Functionally Active Nerve Growth Factor on an Engineered Poly Lactic Glycolic Acid (PLGA) Substrate.
Tissue Engineering Part A, 14 (2008):681-90. [Pubmed]

Linker R, Weller C, Lühder F, Mohr A, Schmidt J, Knauth M, Metselaar JM, Gold R.
Liposomal glucocorticoids in treatment of chronic autoimmune demyelination: Long-term protective effects and enhanced efficacy of methylprednisolone formulations.
Experimental Neurology 211 (2008), 397-406. [Pubmed]

Wüst S, van den Brandt J, Tischner D, Kleiman A, Tuckermann JP, Gold R, Lühder F, Reichardt HM.
Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis.
Journal of Immunology 180 (2008), 8434-8443. [Pubmed]

Linker RA, Lühder F, Kallen KJ, Lee DH, Engelhardt B, Rose-John S, Gold R.
IL-6 transsignalling modulates the early effector phase of EAE and targets the bloo-brain-barrier.
Journal of Neuroimmunology. 205 (2008), 64-72. [Pubmed]

Kruse N, Cetin S, Chan A, Gold R, Lühder F.
Differential expression of BDNF mRNA splice variants in mouse brain and immune cells.
Journal of Neuroimmunology 182 (2007), 13-21. [Pubmed]

Odoardi F, Kawakami N, Klinkert WE, Wekerle H, Flügel A.
Blood-born soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease.
Proceedings of the National Academy of Sciences of the United States of America 104 (2007): 18625-18630. [Pubmed]

Grundtner R, Dornmair K, Dahm R, Flügel A, Kawakami N, Zeitelhofer M, Schoderboeck L, Nosov M, Selzer E, Willheim M, Kiebler M, Wekerle H, Lassmann H, Bradl M.
Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system.
Neurobiology of Disease 28 (2007):261-75. [Pubmed]

Odoardi F, Kawakami N, Li Z, Cordiglieri C, Streyl K, Nosov M, Klinkert WE, Ellwart JW, Bauer J, Lassmann H, Wekerle H, Flügel A.
Instant effect of soluble autoantigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 16 (2007): 920-25. [Pubmed]

Dennehy KM, Elias F, Fischer KD, Hünig T, Lühder F.
Mitogenic CD28 signals utilise the exchange factor Vav1 to amplify TCR signalling at the SLP-76 signalosome.
Journal of Immunology 178 (2007), 1363-1371. [Pubmed]

van den Brandt J, Lühder F, McPherson KG, de Graaf KL, Tischner D, Wiehr S, Herrmann T, Weissert R, Gold R, Reichardt HM.
Enhanced glucocorticoid receptor signalling in T cells impacts on thymocyte apoptosis and adaptive immune responses.
American Journal of Pathology 170 (2007), 1041-53. [Pubmed]

F. Lühder, R. Gold.
Many roads lead to Rome: Heterogeneity among encephalitogenic T cell clones.
Journal of Neuroimmunology 192 (2007), 1-2. [Pubmed]

Cassiani-Ingoni R, Muraro PA, Magnus T, Reichert-Scrivner S, Schmidt J, Huh J, Quandt JA, Bratincsak A, Shahar T, Eusebi F, Sherman LS, Mattson MP, Martin R, Roa MS.
Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response.
Journal Neuropathology Experimental Neurology 66 (2007): 637-649. [Pubmed]

Lunemann JD, Schmidt J, Schmid D, Barthel K, Wrede A, Dalakas MC, Münz C.
β-amyloid is a Substrate of Macroautophagy in Sporadic Inclusion Body Mysositis.
Annals of Neurology 61 (2007): 476-483. [Pubmed]

Lunemann JD, Schmidt J, Dalakas MC, Munz C.
Macroautophagy as a pathomechanism in sporadic inclusion body myositis.
Autophagy 3 (2007): 384-386. [Pubmed]

Gong N, Pleyer U, Vogt K, Anegon I, Flügel A, Volk HD, Ritter T.
Local over-expression of nerve growth factor in corneal transplants improves allograft survival.
Investigative Ophthalmology & Visual Science 48 (2007):1043-1052. [Pubmed]

Salajegheh M, Raju R, Schmidt J, Dalakas MC.
Upregulation of Thrombospondin-1 (TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis.
Journal of Neuroimmunology 187 (2007):166-174. [Pubmed]

Gelderblom H, Schmidt J, Londoño D, Bai Y, Quandt J, Hornung R, Marques A, Martin R, Cadavid D.
Role of Interleukin 10 during Persistent Infection with the Relapsing Fever Spirochete Borrelia turicatae.
American Journal of Pathology 170 (2007): 251-262. [Pubmed]

Linker RA, Mohr A, Cepek L, Gold R, Prange H.
Core hypothermia in multiple sclerosis: case report with magnetic resonance imaging localization of a thalamic lesion.
Case report with MRI localization of a thalamic lesion. Multiple Sclerosis 12 (2006) 112-115. (Pubmed)

Cao Y, Toben C, Na SY, Stark K, Nitschke L, Peterson A, Gold R, Schimpl A, Hünig T.
Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes.
European Journal of Immunology 36 (2006): 207-15. (Pubmed)

Hofstetter H, Toyka KV, Gold R.
Permanent effector phenotype of neuroantigen-specific T cells acquired in the central nervous system during experimental allergic encephalomyelitis.
Neuroscience Letters 391 (2006): 127-30. (Pubmed)

Voigt H, Schrama D, Eggert AO, Vetter CS, Müller-Blech K, Andersen MH, Becker JC, Lühder F.
CD28-mediated costimulation impacts on differentiation of DC-vaccination induced T cell responses.
Clinical Experimental of Immunology. 143 (2006), 93-102. (Pubmed)

Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund FE, Zhang L, Potter BV, Guse AH.
Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives.
British Journal of Pharmacology 149 (2006): 337-44. (Pubmed)

Schrama D, Terheyden P, Otto K, Kammerer U, Brocker EB, Lühder F, Cosman D, Andersen MH, Becker JC.
Expression of the NKG2D ligand UL16 binding protein-1 (ULBP-1) on dendritic cells.
European Journal of Immunology. 36 (2006), 65-72. (Pubmed)

Dennehy KM, Elias F, Zeder-Lutz G, Ding X, Altschuh D, Lühder F, Hünig T.
Monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses.
Journal of Immunology. 176 (2006), 5725-5729. (Pubmed)

Schilling S, Goelz S, Linker R, Lühder F, Gold R.
Fumaric acid esters are effective in chronic EAE and suppress macrophage infiltration.
Clinical Experimental of Immunology. 145 (2006), 101-107. (Pubmed)

Hofstetter H, Lühder F, Toyka KV, Gold R.
IL-17 production by thymocytes upon CD3 stimulation and costimulation with microbial factors.
Cytokine 34 (2006), 184-197. (Pubmed)

Reichardt HM, Gold R, Lühder F.
Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis.
Expert Reviews of Neurotherapeutics 6 (2006), 1657-70. (Pubmed)

Bradl M, Bauer J, Flügel A, Wekerle H, H.
Lassmann. Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord.
American Journal of Pathology, 166 (2005): 1441-50. (Pubmed)

Chan A, Weilbach FX, Toyka KV, Gold R.
Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients.
An ex vivo study Clinical and Experimental Immunology 139 (2005): 152-158. (Pubmed)

Kawakami N, Nägerl UV, Odoardi F, Bonhoeffer T, Wekerle H, Flügel A.
Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion.
Journal of Experimental Medicine, 201 (2005): 1805-14. (Pubmed)

Gold R, Rieckmann P, Chang P, Abdalla J; PRISMS Study Group.
The long-term safety and tolerability of high-dose interferon b-1a in relapsing-remitting multiple sclerosis.
4-year data from the PRISMS study European Journal of Neurology 12 (2005): 649-656. (Pubmed)

Sommer C, Weishaupt A, Brinkhoff J, Biko L, Wessig C, Gold R, Toyka KV.
Paraneoplastic stiff-person syndrome.
Passive transfer to the rat with IgG antibodies to amphiphysin Lancet 365 (2005): 1406-1411. (Pubmed)

Leite MI, Ströbel P, Jones M, Micklem K, Moritz R, Gold R, Niks EH, Berrih-Aknin S, Scaravilli F, Canelhas A, Marx A, Newsom-Davis J, Willcox N, Vincent A.
Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG.
Annals of Neurology 57 (2005): 444-448. (Pubmed)

Kawakami N, Odoardi F, Ziemssen T, Bradl M, Ritter T, Neuhaus O, Lassmann H, Wekerle H, Flügel A.
Autoimmune CD4+ T cell memory: Life long persistence of encephalitogenic T cell clones in healthy immune repertoires.
Journal of Immunology, 175 (2005):69-81. (Pubmed)

Linker RA, Rott E, Hofstetter HH, Hanke T, Toyka KV, Gold R.
EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responses.
Neurobiology of Disease 19 (2005): 218-228. (Pubmed)

Uttner I, Müller S, Zinser C, Maier M, Süßmuth S, Claus A, Ostermann B, Elitok E, Ecker D, Brettschneider J, Gold R, Tumani H.
Reversible impaired memory induced by pulsed methylprednisolone in patients with MS.
Neurology 64 (2005): 1971-1973. (Pubmed)

Vogler S, Goedde R, Miterski B, Gold R, Kroner A, Zettl UK, Rieckmann P, Epplen JT, Ibrahim SM.
Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis.
Journal of Molecular Medicine 83 (2005): 806-11. (Pubmed)

Reinhardt M, Hauff P, Linker RA, Briel A, Gold R, Rieckmann P, Becker G, Toyka KV, Mäurer M, Schirner M.
Ultrasound derived imaging and quantification of cell adhesion molecules in experimental autoimmune encephalomyelitis (EAE) by Sensitive Particle Acoustic Quantification (SPAQ).
Neuroimage 15 (2005): 267-278. (Pubmed)

Beyersdorf N, Gaupp S, Balbach K, Schmidt J, Toyka KV, Lin CH, Hanke T, Hünig T, Kerkau T, Gold R.
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.
Journal of Experimental Medicine 202 (2005): 445-455. (Pubmed)

Thurau SR, Mempel TR, Flügel A, Dietrichs-Möhring M, Krombach F, Kawakami N, Wildner G.
The fate of autoreactive, GFP+ T cells in rat models of uveitis analyzed by intravital fluorescence microscopy and FACS.
International Immunology 16 (2004):1573-82. (Pubmed)

Weilbach FX, Chan A, Toyka KV, Gold R.
The cardioprotector dexrazoxane augments therapeutic efficacy of mitoxantrone in EAE.
Clinical and Experimental Immunology 135 (2004):49-55. (Pubmed)

Visan L, Visan IA, Weishaupt A, Hofstetter HH, Toyka KV, Hünig T, Gold R.
Tolerance induction by intrathymic expression of myelin P0 protein.
Journal of Immunology 172 (2004):1364-70. (Pubmed)

Stoll G, Wesemeier C, Gold R, Solymosi L, Toyka KV, Bendszus M.
In-vivo monitoring of macrophage infiltration in experimental autoimmune neuritis by magnetic resonance imaging.
Journal of Neuroimmunology 149 (2004):142-6. (Pubmed)

Kawakami N, Lassmann S, Li Z, Odoardi F, Ritter T, Ziemssen T, Klinkert WE, Ellwart JW, Bradl M, Krivacic K, Lassmann H, Ransohoff RM, Volk HD, Wekerle H, LiningtonC, Flügel A.
The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis.
Journal of Experimental Medicine 199 (2004): 185-197. (Pubmed)

Weishaupt A, Kreiss M, Gold R, Herrmann T.
Modulation of experimental autoimmune encephalomyelitis by administration of cells expressing antigenic peptide covalently linked to MHC class II.
Journal of Neuroimmunology 152 (2004):11-19. (Pubmed)

Wellmer A, von Mering M1, Spreer A, Diem R, Eiffert H, Noeske C, Bunkowski S, Gold R, Nau R.
Experimental Pneumococcal Meningitis: Impaired Clearance of Bacteria from the Blood in Bcl-2-deficient Mice due to Increased Apoptosis in the Spleen.
Infection and Immunity 72 (2004):3113-19. (Pubmed)

Linker RA, Gold R.
MBP-induced experimental autoimmune encephalomyelitis in C57BL/6 mice.
J Immunol. 2004 Sep 1;173(5):2896. (Pubmed)

Aboul-Enein F, Bauer J, Klein M, Schubart A, Flügel A, Ritter T, Kawakami N, Siedler F, Linington C, WekerleH, Lassmann H, Bradl M.
Selective and Antigen dependent effects of myelin degeneration on Central Nervous System inflammation.
Journal of Neuropathology and Experimental Neurology 63 (2004): 1284-96. (Pubmed)

Ströbel P, Bauer A, Puppe B, Kraushaar T, Krein A, Toyka K, Gold R, Semik M, Kiefer R, Nix W, Schalke B, Müller-hermelink HK, Marx A.
Tumor Recurrence and Survival in Patients Treated for Thymomas and Thymic Squamous Cell Carcinomas: A Retrospective Analysis.
Journal of Clinical Oncology 22 (2004):1501-9. (Pubmed)

Ruprecht K, Klinker E, Dintelmann T, Rieckmann P, Gold R.
Plasma Exchange in the Treatment of Severe Optic Neuritis.
Analysis of a Series of 10 Patients Neurology 63 (2004): 1081-1083. (Pubmed)

Schmidt J, Rakocevic G, Raju R, Dalakas MC.
Upregulated inducible co-stimulator (ICOS) and ICOS-ligand in inclusion body myositis muscle: significance for CD8+ T cell cytotoxicity.
Significance for CD8+ T cell Cytotoxicity. Brain 127 (2004): 1182-90. (Pubmed)